Diabetic foot ulcers (DFUs) are a devastating ailment for many diabetic patients with
increasing prevalence and morbidity. The complex pathophysiology of DFU wound …

Inflammation is strictly interconnected to anti-inflammatory mechanisms to maintain tissue
homeostasis. The disruption of immune homeostasis can lead to acute and chronic …

Pemphigoid diseases refer to a group of severe autoimmune skin blistering diseases
characterized by subepidermal blistering and loss of dermal-epidermal adhesion induced by …

Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …

Autoimmune diseases often present with cutaneous symptoms that contribute to dysfunction,
disfigurement, and in many cases, reduced quality-of-life. Unfortunately, treatment options …

Granzymes are a family of small (∼ 32 kDa) serine proteases with a range of substrate
specificities that are stored in, and released from, the cytoplasmic secretory vesicles …

Chronic inflammation and impaired wound healing play important roles in the
pathophysiology of cardiovascular diseases. Moreover, the aberrant secretion of proteases …

Genital herpes is characterized by recurrent episodes of epithelial blistering. The
mechanisms causing this pathology are ill defined. Using a mouse model of vaginal herpes …

Atopic dermatitis (AD) is the most common inflammatory skin condition. Skin barrier
dysfunction is of major importance in AD because it facilitates allergen sensitization and …

Immune cells are known to be critical for successful limb regeneration in the axolotl
(Ambystoma mexicanum), but many details regarding their identity, behavior, and function …