Recently, several advances have been made in the understanding of the form and function
of archaeal chromatin. Remarkable parallels can be drawn between the structure and …

Isothermal titration calorimetry (ITC) is becoming widely accepted as a key instrument in any
laboratory in which quantification of biomolecular interactions is a requisite. The method has …

The CRISPR–Cas system for prokaryotic adaptive immunity provides RNA-mediated
protection from viruses and mobile genetic elements. Adaptation is dependent on the Cas1 …

Members of the Sso7d/Sac7d family are small, abundant, non-specific DNA-binding proteins
of the hyperthermophilic Archaea Sulfolobus. Crystal structures of these proteins in complex …

N‐terminal protein acetylation is common in eukaryotes and halophilic archaea, but very
rare in bacteria. We demonstrate that some of the most abundant proteins present in the …

Two archaeal Holliday junction resolving enzymes, H olliday j unction c leavage (Hjc) and H
olliday j unction e ndonuclease (Hje), have been characterized. Both are members of a …

Protein–DNA interactions underpin life and play key roles in all cellular processes and
functions including DNA transcription, packaging, replication, and repair. Identifying and …

Viruses infect members of domains Bacteria, Eukarya, and Archaea. While those infecting
domain Eukarya are nearly universally described as “Viruses”, those of domain Bacteria, to …

Protein-DNA interactions underpin life and play key roles in all cellular processes and
functions including DNA transcription, packaging, replication, and repair. Identifying and …

Helicases and nucleases form complexes that play very important roles in DNA repair
pathways some of which interact with each other at Holliday junctions. In this study, we …