As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Breast cancer is the cancer with the highest prevalence in women and is the number‐one
cause of cancer mortality worldwide. Cell transduction is a fundamental process in the …

Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and
aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by …

The frequent activation of the PI3K/AKT/mTOR pathway and its crucial role in estrogen
receptor-positive (ER+) breast cancer tumorigenesis and drug resistance has made it a …

Endocrine therapy is a crucial treatment for estrogen receptor-positive (ER+) breast cancer,
with proven clinical benefits. However, adaptive mechanisms emerge in the tumor, causing …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

Abstract PI3K/AKT signaling pathway plays an important role in tumorigenesis and regulates
critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations …

Aberrant glycosylation is a universal feature of cancer cells and there is now overwhelming
evidence that glycans can modulate pathways intrinsic to tumour cell biology. Glycans are …

Purpose Recent data showed improvement in progression-free survival (PFS) when adding
everolimus to exemestane in patients with advanced breast cancer experiencing recurrence …

Breast cancer is a common malignancy with current biological therapies tailored to steroid
hormone (ER, PR) and HER2 receptor status. Understanding the biological basis of …