Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-
related disorder characterized by loss of skeletal muscle mass and function, is recognized …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline and memory loss. Despite advances in understanding the …

Inhibiting glycogen synthase kinase 3 (GSK3) improves muscle function, metabolism, and
bone health in many diseases and conditions; however, whether GSK3 should be targeted …

The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation
causes a syndromic form of autism spectrum disorder (ASD): Phelan-McDermid Syndrome …

Introduction: This study aimed to estimate all-cause mortality in patients after a first-episode
mania (FEM) and examine whether six guideline-recommended medications can reduce …

Background With increasing age, the social and economic burdens of postmenopausal
osteoporosis are steadily increasing. This study aimed to investigate the factors that …

Ischemic stroke ranks among the foremost clinical causes of mortality and disability,
instigating neuronal degeneration, fatalities, and various sequelae. While standard …

Impaired iron metabolism has been increasingly observed in many diseases, but a deeper,
mechanistic understanding of the cellular impact of altered iron metabolism is still lacking. In …

This study delves into the relationship between environmental metal exposure and QT
interval corrected for heart rate (QTc) prolongation, a critical marker for cardiovascular risk in …