The direct introduction of diverse fluorinated motifs into feedstock molecules and advanced
intermediates is widely studied in pharmaceutical research and drug development. Among …

This review describes recent advances in difluoroalkylation reactions using different
substrates. Generally speaking, RCF2 radical is generally proposed in the mechanism of …

A palladium‐catalyzed reductive difluorocarbene transfer reaction that tames
difluorocarbene to couple with two electrophiles has been developed, representing a new …

Difluorocarbene has important applications in pharmaceuticals, agrochemicals and
materials, but all these applications proceed using just a few types of reaction by taking …

Recent protocols and reactions for catalytic radical perfluoroalkylations will be described.
The production of perfluoroalkyl radicals (RF= C n F2 n+ 1, n≥ 2), which effect both addition …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Defluorinative manipulation of polyfluorinated molecules has shown great promise due to its
granting of synthetic versatility to inert C− F bonds. The development of chemo‐, stereo‐and …

Herein, we report a ligand-controlled palladium-catalyzed method that enables the synthesis
of ynones and γ-butenolides with excellent regioselectivity from the same set of readily …

Direct synthesis of gem‐difluorinated carbocyclic molecules represents a longstanding
challenge in organic chemistry. Herein, a Rh‐catalyzed [3+ 2] cycloaddition reaction …

This review summarizes the progress in the fluorination and fluoroalkylation of electron‐rich
systems with diverse fluorine (F) and fluoroalkyl (Rfn) reagents employing hypervalent …