▪ Abstract GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by
increasing the rates at which their α subunits hydrolyze bound GTP and thus return to the …

▪ Abstract Phototransduction is the process by which a photon of light captured by a
molecule of visual pigment generates an electrical response in a photoreceptor cell …

Signaling pathways that link extracellular factors to activation of the monomeric guanosine
triphosphatase (GTPase) Rho control cytoskeletal rearrangements and cell growth …

Vision is the most fundamental of our senses initiated when photons are absorbed by the
rod and cone photoreceptor neurons of the retina. At the distal end of each photoreceptor …

A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to
specific effector target molecules. The G protein transducin, Gt, couples photon-activated …

Pertussis toxin (PTX) has been widely used as a reagent to characterize the involvement of
heterotrimeric G-proteins in signalling. This toxin catalyses the ADP-ribosylation of specific G …

Proteins of the regulators of G protein signaling (RGS) family modulate the duration of
intracellular signaling by stimulating the GTPase activity of G protein α subunits. It has been …

The phospholipase C-β1 (PLC-β1) signaling pathway was reconstituted by addition of
purified PLC to phospholipid vesicles that contained purified recombinant m1 muscarinic …

Heterotrimeric guanosine 5′-triphosphate (GTP)–binding proteins (G proteins) are
deactivated by hydrolysis of the GTP that they bind when activated by transmembrane …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …