Chromatin is a highly regulated, modular nucleoprotein complex that is central to many
processes in eukaryotes. The organization of DNA into nucleosomes and higher-order …

The core histone tail domains are “master control switches” that help define the structural
and functional characteristics of chromatin at many levels. The tails modulate DNA …

Acetylation of the N-terminal tails of the core histones directly facilitates the recognition by
TFlllA of the 5s RNA gene wlthin model chromatin templates. This effect is independent of a …

Using immobilized trypsin and an appropriate fractionation procedure, we have been able to
prepare, for the first time, nucleosome core particles containing selectively trypsinized …

Using competitive reconstitution, we have refined the parameters for the binding of histone
octamers to artificial nucleosome-positioning sequences of the form:(A/T 3 nn (G/C) 3 nn. We …

We have studied the reversible dissociation of core size DNA from chicken erythrocyte
nucleosome core particles in solutions containing 0.1 m to 0.6 m-NaCl. Dissociation …

The process of mononucleosome assembly mediated by histone chaperone NAP1 was
investigated using DNA fragments 146 and 207 bp in length containing the Lytechinus …

Each of the core histone proteins within the nucleosome has a central “structured” domain
that comprises the spool onto which the DNA superhelix is wrapped and an N-terminal “tail” …

Tight packaging of DNA in chromatin severely constrains DNA accessibility and dynamics. In
contrast, nucleosomes in active chromatin state are highly flexible, can exchange their …

IgG reactivity with the (H2A-H2B)-DNA complex, a subunit of the nucleosome, has been
detected in many patients with lupus induced by procainamide and quinidine, but the …