Atypical renal clearance of nanoparticles larger than the kidney filtration threshold

CF Adhipandito, SH Cheung, YH Lin… - International journal of …, 2021 - mdpi.com
In recent years, several publications reported that nanoparticles larger than the kidney
filtration threshold were found intact in the urine after being injected into laboratory mice …

Diabetic proteinuria revisited: updated physiologic perspectives

SN Heyman, I Raz, JP Dwyer, R Weinberg Sibony… - Cells, 2022 - mdpi.com
Albuminuria, a hallmark of diabetic nephropathy, reflects not only injury and dysfunction of
the filtration apparatus, but is also affected by altered glomerular hemodynamics and …

Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis

H Yu, T Lin, W Chen, W Cao, C Zhang, T Wang, M Ding… - Biomaterials, 2019 - Elsevier
Acute kidney injury (AKI) is associated with high mortality and morbidity with no effective
treatment available at present, which greatly escalates the risk of chronic kidney disease …

Research progress on multiple cell death pathways of podocytes in diabetic kidney disease

C Yang, Z Zhang, J Liu, P Chen, J Li, H Shu, Y Chu… - Molecular …, 2023 - Springer
Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …

Renal handling of albumin—from early findings to current concepts

J Gburek, B Konopska, K Gołąb - International journal of molecular …, 2021 - mdpi.com
Albumin is the main protein of blood plasma, lymph, cerebrospinal and interstitial fluid. The
protein participates in a variety of important biological functions, such as maintenance of …

Diabetic nephropathy: is it always there? Assumptions, weaknesses and pitfalls in the diagnosis

K Ioannou - Hormones, 2017 - Springer
Diabetic nephropathy is defined as a microvascular complication of the kidneys induced by
diabetes mellitus and is characterized by albuminuria and progressive loss of kidney …

Modes of podocyte death in diabetic kidney disease: an update

A Jiang, A Song, C Zhang - Journal of Nephrology, 2022 - Springer
Diabetic kidney disease (DKD) accounts for a large proportion of end-stage renal diseases
that require renal replacement therapies including dialysis and transplantation. Therefore, it …

Potential relationship between eGFRcystatin C/eGFRcreatinine‐ratio and glomerular basement membrane thickness in diabetic kidney disease

CM Öberg, M Lindström, A Grubb… - Physiological …, 2021 - Wiley Online Library
Diabetic kidney disease (DKD) is a leading cause of end‐stage renal disease and renal
replacement therapy worldwide. A pathophysiological hallmark of DKD is glomerular basal …

From protein uptake to Dent disease: an overview of the CLCN5 gene

L Gianesello, D Del Prete, M Ceol, G Priante, LA Calò… - Gene, 2020 - Elsevier
Proteinuria is a well-known risk factor, not only for renal disorders, but also for several other
problems such as cardiovascular diseases and overall mortality. In the kidney, the chloride …

Oxidized albumin as a mediator of kidney disease

SM Figueroa, P Araos, J Reyes, B Gravez… - Antioxidants, 2021 - mdpi.com
Renal diseases are a global health concern, and nearly 24% of kidney disease patients are
overweight or obese. Particularly, increased body mass index has been correlated with …