Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

There is a growing attention toward personalized medicine. This is led by a fundamental
shift from the 'one size fits all'paradigm for treatment of patients with conditions or …

Single-cell transcriptomic analysis is widely used to study human tumors. However, it
remains challenging to distinguish normal cell types in the tumor microenvironment from …

Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …

We conducted next-generation DNA sequencing on 335 biliary tract cancers and
characterized the genomic landscape by anatomic site within the biliary tree. In addition to …

Large oncology repositories have paired genomic and transcriptomic data for all patients.
We used these data to perform two independent analyses: to identify gene expression …

The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma
(MCL) are incompletely understood. We characterize the cellular and molecular …

Abstract Frizzled (Fzd) proteins are Wnt receptors and play essential roles in development,
homeostasis, and oncogenesis. How Wnt/Fzd signaling is coupled to physiological …

Cancers avoid immune surveillance through an array of mechanisms, including perturbation
of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I …

Testing of patients with genetics-related disorders is in progress of shifting from single gene
assays to gene panel sequencing, whole-exome sequencing (WES) and whole-genome …