The function of melanin or six blind people examine an elephant

HZ Hill - Bioessays, 1992 - Wiley Online Library
The pigment melanin is found in all living kingdoms and in many different structures and
forms. When its various functions are examined separately, its behaviors seem disparate …

Mechanisms of photodamage of the skin and its functional consequences for skin ageing

F Trautinger - Clinical and experimental dermatology, 2001 - academic.oup.com
Chronic photodamage of the skin manifests itself as extrinsic skin ageing (photoageing) and
photocarcinogenesis. DNA photodamage and UV‐generated reactive oxygen species are …

Superoxide anion generation in Drosophila during melanotic encapsulation of parasites.

AJ Nappi, E Vass, F Frey, Y Carton - European journal of cell …, 1995 - europepmc.org
Quinoid precursors of melanin and/or reactive oxygen species (ROS) generated during
melanogenesis have been implicated as cytotoxic molecules in the immune responses of …

Ultrastructural Organization of Eumelanin from Sepia officinalis Measured by Atomic Force Microscopy

CMR Clancy, JD Simon - Biochemistry, 2001 - ACS Publications
Atomic force microscopy is used to investigate the structural organization of eumelanin
isolated from the inks sacs of the cuttlefish Sepia officinalis. Deposits of eumelanin on mica …

Spectroscopic and Dynamic Studies of the Epidermal Chromophores trans-Urocanic Acid and Eumelanin

JD Simon - Accounts of Chemical Research, 2000 - ACS Publications
Photoaging and skin cancer can result from the exposure of skin to ultraviolet A (UV-A, 320−
400 nm) radiation. The detailed chemical mechanisms by which these processes occur are …

Binding of Metal Ions to Melanin and Their Effects on the Aerobic Reactivity

L Hong, Y Liu, JD Simon - Photochemistry and photobiology, 2004 - Wiley Online Library
The binding of Mg (II), Ca (II), Zn (II), Cu (II) and Fe (III) to ETDA‐washed Sepia melanin is
quantified by inductively coupled plasma mass spectrometry. By monitoring the solution pH …

Wavelength‐dependent photoacoustic calorimetry study of melanin

SE Forest, JD Simon - Photochemistry and photobiology, 1998 - Wiley Online Library
Photoacoustic calorimetry is used to examine the energy dissipation in melanin under
physiological conditions (pH 7.2) following irradiation by UV and visible (VIS) light. Four …

The probable involvement of soluble and deposited melanins, their intermediates and the reactive oxygen side-products in human diseases and aging

ZL Hegedus - Toxicology, 2000 - Elsevier
The plasma soluble melanins (PSM) form spontaneously in vitro and in vivo and their
formation involves oxidative polymerization and copolymerization of dopa, catecholamines …

Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and …

A Ungvari, T Kiss, R Gulej, S Tarantini, B Csik… - GeroScience, 2024 - Springer
Hair graying, also known as canities or achromotrichia, is a natural phenomenon associated
with aging and is influenced by external factors such as stress, environmental toxicants, and …

Melanosomal Damage in Normal Human Melanocytes Induced by UVB and Metal Uptake—A Basis for the Pro‐oxidant State of Melanoma

S Gidanian, M Mentelle… - Photochemistry and …, 2008 - Wiley Online Library
Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes
within melanocytes, the function of which is to protect skin against harmful effects of UV …