Publisher Summary This chapter focuses on neuregulins (NRGs) that are the signaling
proteins that mediate cell–cell interactions in the nervous system, heart, breast, and other …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

Genes encoding homeodomain-containing proteins potentially involved in endocrine
pancreas development were isolated by combined in silico and nested-PCR approaches …

Neuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase
receptors of the ErbB family. Neuregulin signals are also involved in the development …

Shortage in tissue availability from cadaver donors and the need for life-long
immunosuppression severely restrict the large-scale application of cell-replacement therapy …

Organogenesis is a complex process that relies on a dynamic interplay between extrinsic
factors originating from the microenvironment and tissue-specific intrinsic factors. For …

Publisher Summary This chapter focuses on the ErbB-4 receptor, which is cloned from a
human mammary carcinoma cell line and shows to be related in sequence to other ErbB …

Adipose tissue has been shown to play a key role in energy metabolism and it has been
shown to regulate metabolic homeostasis through the secretion of adipokines. Neuregulin 4 …

Motivation: The power of a microarray experiment derives from the identification of genes
differentially regulated across biological conditions. To date, differential regulation is most …