Hemophilia A and B are rare X‐linked inherited bleeding disorders caused by complete or
partial deficiency in or the absence of coagulation factors VIII and IX. Recurrent joint …

Spontaneous joint bleeding and repeated hemarthroses lead to hemophilic arthropathy—a
debilitating disease with a significant negative impact on mobility and quality of life. Iron …

Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with
hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of …

Haemarthroses cause major morbidity in patients with haemophilia. Blood has devastating
effects on all joint components, resulting in synovitis, osteochondral degeneration and …

The pathogenetic mechanism of haemophilic arthropathy is multifactorial and includes
degenerative cartilage‐mediated and inflammatory synovium‐mediated components. Intra …

Hemophilia is a congenital clotting factor deficiency characterized by spontaneous and
trauma-related bleeding. Spontaneous bleeding shows a predilection for joints, and …

Haemophilic arthropathy, which shares some clinical and biological injury characteristics
with rheumatoid arthritis, is characterized by two main features: chronic proliferative synovitis …

Currently available factor concentrates for treatment of patients with haemophilia are virally
inactivated or are made by recombinant technology and their broad use in developed …

Haemophilic arthropathy is joint damage evolving from recurrent joint bleeds that occur in
patients suffering from the clotting disorder haemophilia. Insight into the pathogenetic …

Haemarthroses (intra‐articular haemorrhages) are a frequent finding typically observed in
patients with haemophilia. Diagnosis and treatment of these bleeding episodes must be …