Obesity, a growing health problem worldwide, has been associated with the metabolic
syndrome, diabetes, cardiovascular disease, hypertension, and other chronic diseases …

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and …

Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL)
is one of several members of the TNF gene superfamily that induce apoptosis through …

The present review will explore the insights gained into inositol pyrophosphates in the 20
years since their discovery in 1993. These molecules are defined by the presence of the …

Discovered as antiviral cytokines, interferons (IFNs) are now also recognized for their
capacity to inhibit the growth of malignant cells via activation of programmed cell death …

A number of methods have been developed to examine the morphologic, biochemical, and
molecular changes that happen during the DNA damage response that may ultimately lead …

Inositol pyrophosphates are highly energetic inositol polyphosphate molecules present in
organisms from slime molds and yeast to mammals. Distinct classes of enzymes generate …

Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that
have a range of signaling functions. Since the discovery of inositol pyrophosphates in the …

The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-
kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM. These kinases are …