The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and
survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK …

Ibrutinib (Imbruvica™) is an irreversible, potent inhibitor of Bruton's tyrosine kinase (BTK).
Over the last few years, ibrutinib has developed from a promising drug candidate to being …

Glioblastoma (GBM) is the most lethal primary brain tumor and is highly resistant to current
treatments. GBM harbors glioma stem cells (GSCs) that not only initiate and maintain …

Protein tyrosine kinases (PTKs) are enzymes that transfer phosphate groups to tyrosine
residues on protein substrates. Phosphorylation of proteins causes changes in their function …

Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting
lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial …

The cardiovascular system is composed around the central function of the endothelium that
lines the inner surfaces of its vessels. In recent years, the existence of a progenitor …

Rationale: BMX (bone marrow kinase on the X chromosome) is highly expressed in the
arterial endothelium from the embryonic stage to the adult stage in mice. It is also expressed …

Purpose: Epithelial and endothelial tyrosine kinase (Etk), also known as bone marrow X
kinase (Bmx), was found to be critical in modulating the chemoresistance of small-cell lung …

The collection of chemically different protein variants, or proteoforms, by far exceeds the
number of protein-coding genes in the human genome. Major contributors are alternative …

Tyrosine phosphorylation by protein tyrosine kinases (PTKs) is a type of post-translational
modification. Tec kinases, which are a subfamily of non-receptor PTKs, were originally …