The MHC class II transactivator CIITA: not (quite) the odd-one-out anymore among NLR proteins
JA León Machado, V Steimle - International journal of molecular sciences, 2021 - mdpi.com
In this review, we discuss the major histocompatibility complex (MHC) class II transactivator
(CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding …
(CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding …
[HTML][HTML] The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy
G Forlani, M Shallak, A Gatta, AKB Shaik, RS Accolla - biomedical journal, 2023 - Elsevier
Human nucleotide-binding oligomerization domain (NOD)-like receptors (NLR) include a
large family of proteins that have important functions in basic physio-pathological processes …
large family of proteins that have important functions in basic physio-pathological processes …
MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses
Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our …
2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our …
[PDF][PDF] Molecular and cellular interactions of HIV-1/HTLV coinfection and impact on AIDS progression
C Casoli, E Pilotti, U Bertazzoni - Aids Rev, 2007 - academia.edu
In the last 10 years HIV-1/human T-cell leukemia virus (HIV-1/HTLV) coinfection has
emerged as a worldwide health problem. The numbers of HIV-1/HTLV-1 coinfections in …
emerged as a worldwide health problem. The numbers of HIV-1/HTLV-1 coinfections in …
The major histocompatibility complex class II transactivator CIITA inhibits the persistent activation of NF-κB by the human T cell lymphotropic virus type 1 Tax-1 …
G Forlani, R Abdallah, RS Accolla, G Tosi - Journal of Virology, 2016 - Am Soc Microbiol
Human T cell lymphotropic virus type 1 (HTLV-1) Tax-1, a key protein in HTLV-1-induced T
cell transformation, deregulates diverse cell signaling pathways. Among them, the NF-κB …
cell transformation, deregulates diverse cell signaling pathways. Among them, the NF-κB …
HTLV-1/-2 and HIV-1 co-infections: retroviral interference on host immune status
E Pilotti, MV Bianchi, A De Maria, F Bozzano… - Frontiers in …, 2013 - frontiersin.org
The human retroviruses HIV-1 and HTLV-1/HTLV-2 share similar routes of transmission but
cause significantly different diseases. In this review we have outlined the immune mediated …
cause significantly different diseases. In this review we have outlined the immune mediated …
Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1
G Forlani, M Shallak, E Ramia, A Tedeschi, RS Accolla - Retrovirology, 2019 - Springer
Background Immunity against pathogens evolved through complex mechanisms that only for
sake of simplicity are defined as innate immunity and adaptive immunity. Indeed innate and …
sake of simplicity are defined as innate immunity and adaptive immunity. Indeed innate and …
[HTML][HTML] Class II transactivator restricts viral replication, extending its effect to HBV: Editorial on “Novel role of MHC class II transactivator in hepatitis B virus replication …
Class II transactivator restricts viral replication, extending its effect to HBV: Editorial on “Novel
role of MHC class II transactivator in hepatitis B virus replication and viral counteraction” - PMC …
role of MHC class II transactivator in hepatitis B virus replication and viral counteraction” - PMC …
Mechanisms of innate immune sensing of HTLV-1 and viral immune evasion
Human T lymphotropic virus-1 (HTLV-1) was the first identified oncoretrovirus, which infects
and establishes a persistent infection in approximately 10–20 million people worldwide …
and establishes a persistent infection in approximately 10–20 million people worldwide …
Major histocompatibility complex class II transactivator CIITA is a viral restriction factor that targets human T-cell lymphotropic virus type 1 Tax-1 function and inhibits …
G Tosi, G Forlani, V Andresen, M Turci… - Journal of …, 2011 - Am Soc Microbiol
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of an aggressive
malignancy of CD4+ T lymphocytes. Since the viral transactivator Tax-1 is a major player in …
malignancy of CD4+ T lymphocytes. Since the viral transactivator Tax-1 is a major player in …