Alzheimer′ s disease (AD) is the most common type of dementia. In connection with the
global trend of prolonging human life and the increasing number of elderly in the population …

Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …

We recommend a new term,“primary age-related tauopathy”(PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

Objective Mixed pathologies are common in older persons with dementia. Little is known
about mixed pathologies in probable Alzheimer disease (AD) and about the spectrum of …

Aims Phosphorylation, conformational changes and cleavage of tau protein have been
widely suggested to contribute to abnormal tau processing in the pathogenesis of A …

Since the earliest descriptions of Alzheimer's disease (AD), many theories have been
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …

Abnormally phosphorylated tau accumulates as neurofibrillary tangles and neuropil threads
in older persons with and without Alzheimer's disease. The relationship between …

Neurofibrillary tangles (NFT) and dystrophic neurites represent dense cytoplasmic
accumulations of abnormal polymers in the brain of patients with Alzheimer's disease (AD) …

Revised: 4 March 2015/Accepted: 4 March 2015/Published online: 17 March 2015©
Springer-Verlag Berlin Heidelberg 2015 are commonly observed in extreme old age [9, 15 …

A multitiered strategy was adopted to assess tau conformational changes within fibrillar
lesions during the progression of Alzheimer's disease (AD). Anti-tau monoclonal antibodies …