Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis

H Zhang, Y Wang, M Qu, W Li, D Wu… - Clinical and …, 2023 - Wiley Online Library
Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

Understanding tumour endothelial cell heterogeneity and function from single-cell omics

Q Zeng, M Mousa, AS Nadukkandy, L Franssens… - Nature Reviews …, 2023 - nature.com
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

Renal endothelial cell‐targeted extracellular vesicles protect the kidney from ischemic injury

K Zhang, R Li, X Chen, H Yan, H Li, X Zhao… - Advanced …, 2023 - Wiley Online Library
Endothelial cell injury plays a critical part in ischemic acute kidney injury (AKI) and
participates in the progression of AKI. Targeting renal endothelial cell therapy may …

[HTML][HTML] Sepsis Biomarkers: Advancements and Clinical Applications—A Narrative Review

RR He, GL Yue, ML Dong, JQ Wang… - International journal of …, 2024 - mdpi.com
Sepsis is now defined as a life-threatening syndrome of organ dysfunction triggered by a
dysregulated host response to infection, posing significant challenges in critical care. The …

GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response

T Dusabimana, J Je, SP Yun, HJ Kim, H Kim… - Cell Death & …, 2023 - nature.com
Sepsis is a serious clinical condition characterized by a systemic inflammatory response, a
leading cause of acute liver and kidney injury, and is associated with a high morbidity and …

Sepsis-induced AKI: From pathogenesis to therapeutic approaches

FF He, YM Wang, YY Chen, W Huang, ZQ Li… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by
infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and …

[HTML][HTML] Endothelial dysfunction: Pathophysiology and therapeutic targets for sepsis-induced multiple organ dysfunction syndrome

F Tang, XL Zhao, LY Xu, JN Zhang, H Ao… - Biomedicine & …, 2024 - Elsevier
Sepsis and septic shock are critical medical conditions characterized by a systemic
inflammatory response to infection, significantly contributing to global mortality rates. The …

The pathophysiology of sepsis-associated AKI

S Kuwabara, E Goggins, MD Okusa - Clinical Journal of the …, 2022 - journals.lww.com
Sepsis-associated AKI is a life-threatening complication that is associated with high
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …

Renal tubular epithelial cells response to injury in acute kidney injury

ZL Li, XY Li, Y Zhou, B Wang, LL Lv, BC Liu - EBioMedicine, 2024 - thelancet.com
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid and significant
decrease in renal function that can arise from various etiologies, and is associated with high …

Role of the renin angiotensin aldosterone system in the pathogenesis of sepsis-induced acute kidney injury: a systematic review

S Tibi, G Zeynalvand, H Mohsin - Journal of Clinical Medicine, 2023 - mdpi.com
Background: Sepsis is a life-threatening condition responsible for up to 20% of all global
deaths. Kidneys are among the most common organs implicated, yet the pathogenesis of …