Background An assessment of the correlation between anti-malarial treatment outcome and
molecular markers would improve the early detection and monitoring of drug resistance by …

Resistance to quinoline antimalarials, especially to chloroquine and mefloquine has had a
major impact on the treatment of malaria worldwide. In the period since 2000, significant …

Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the
digestive vacuole transmembrane protein PfCRT. However, the contribution of individual …

Mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate
synthase (dhps) genes have been used as means to predict treatment failure to sulfadoxine …

We assessed Plasmodium falciparum mdr1 (Pf mdr1) gene polymorphisms and copy
numbers as well as P. falciparum Ca2+ ATPase (Pf ATPase6) gene polymorphisms in 90 …

This study investigated the association between Plasmodium falciparum chloroquine
resistance transporter (pfcrt) T76 and P. falciparum multidrug resistance gene 1 (pfmdr1) …

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant
of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are …

Parasite genotyping by a polymerase chain reaction was used to distinguish recrudescent
from newly acquired Plasmodium falciparum infections in 50 of 160 Nigerian children taking …

The efficacy of 3-day regimens of artemether-lumefantrine and artesunate-amodiaquine
were evaluated in 747 children< 5 years of age with uncomplicated malaria from six …

Background A reversal of chloroquine (CQ) resistance following a period of withdrawal has
raised the possibility of its re-introduction. This study evaluated the current prevalence of …