The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Niches are local tissue microenvironments that maintain and regulate stem cells. Long-
predicted from mammalian studies, these structures have recently been characterized within …

The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

After partitioning of cytoplasmic contents by cleavage furrow ingression, animal cells remain
connected by an intercellular bridge, which subsequently splits by abscission. Here, we …

TSG101 and ALIX both function in HIV budding and in vesicle formation at the multivesicular
body (MVB), where they interact with other Endosomal Sorting Complex Required for …

During cytokinesis, as dividing animal cells pull apart into two daughter cells, the final stage,
termed abscission, requires breakage of the midbody, a thin membranous stalk connecting …