In recent years, substantial research has been conducted on molecular mechanisms and
inhibitors targeting bromodomains (BRDs) and extra-terminal (BET) family proteins. On this …

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

Macrophage activation is a critical step in host responses during bacterial infections.
Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has …

Parasitic infections remain one of the most pressing global health concerns of our day,
affecting billions of people and producing unsustainable economic burdens. The rise of drug …

Parasites of the Apicomplexa phylum, such as Plasmodium spp. and Toxoplasma gondii,
undergo complex life cycles involving multiple stages with distinct biology and …

Proteome-wide lysine acetylation has been documented in apicomplexan parasite
Toxoplasma gondii and Plasmodium falciparum. Here, we conducted the first lysine …

Histone‐modifying enzymes are the key regulators involved in the post‐translational
modification of histone and non‐histone. These enzymes are responsible for the epigenetic …

Over the past thirty years, epigenetic regulation of gene expression has gained increasing
interest as it was shown to be implicated in illnesses ranging from cancers to parasitic …

Abnormal differentiation of muscle is closely associated with aging (sarcopenia) and
diseases such as cancer and type II diabetes. Thus, understanding the mechanisms that …

Literature evidence that natural products are potential bioactive components for lead
compounds in drug discovery. These molecules have distinctive chemical structures that …