Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …

Abstract Fibroblast growth factor 8 (FGF‐8), also known as androgen‐induced growth factor
(AIGF), is presumed to be a potent mitogenic cytokine that plays important roles in early …

Calvarial bone is one of the most complex sequences of developmental events in
embryology, featuring a uniquely transient, pluripotent stem cell-like population known as …

Receptor tyrosine kinase-mediated growth factor signaling is essential for proper formation
and development of the neural crest. The many ligands and receptors implicated in these …

Craniofacial development comprises a complex process in humans in which failures or
disturbances frequently lead to congenital anomalies. Cleft lip with/without palate (CL/P) is a …

The fibroblast growth factors (FGFs) play a critical role during palatogenesis by mediating a
variety of cellular responses. Extensive epidemiological and genetic studies over several …

Knowledge of cell signaling pathways that drive human neural crest differentiation into
craniofacial chondrocytes is incomplete, yet essential for using stem cells to regenerate …

骨骼正常发育和稳态维持是人体正常行使功能的重要前提， 如果出现骨骼发育畸形或者稳态
紊乱， 如颅缝早闭、 腭裂、 大骨节病和骨关节炎等， 对患者个人的生活， 甚至家庭 …