There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

The concept that adenine and uridine nucleotides function as extracellular signaling
molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated …

T-cell activation requires the influx of extracellular calcium, although mechanistic details
regarding such activation are not fully defined. Here, we show that P2X 7 receptors play a …

All cells release nucleotides and are in one way or another involved in local autocrine and
paracrine regulation of organ function via stimulation of purinergic receptors. Significant …

ATP can be released from a variety of cell types by mechanical stimulation; however, the
mechanism for this release and the influence of pathology are not well understood. The …

Nucleotides within the airway surface liquid (ASL) regulate airway epithelial ion transport
rates by Ca 2+-and protein kinase C-dependent mechanisms via activation of specific P2Y …

purpose. Intercellular Ca 2+ wave propagation is a distinct form of cell–cell communication.
In corneal endothelial cells, intercellular Ca 2+ wave propagation evoked by a point …

The hypothesis that regulated ATP release from red blood cells (RBCs) contributes to nitric
oxide-dependent control of local blood flow has sparked much interest in underlying release …

Intercellular communication (IC) is mediated by gap junctions (GJs) and hemichannels,
which consist of proteins. This has been particularly well documented for the connexin (Cx) …

Abstract Extracellular adenosine 5′-triphosphate (ATP) was proposed to be an activity-
dependent signaling molecule that regulates glia–glia and glia–neuron communications …