The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …

Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Short-chain fatty acids (SCFAs), the main metabolites produced by bacterial fermentation of
dietary fibre in the gastrointestinal tract, are speculated to have a key role in microbiota–gut …

Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

The gut microbiota (GM) plays an important role in the physiology and pathology of the host.
Microbiota communicate with different organs of the organism by synthesizing hormones …

There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

Highlights•GLP-1 analogs can cross the blood–brain barrier and stimulate the GLP-1
receptor in the brain.•Stimulation of the GLP-1 receptor has shown effects on mitochondrial …

Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective
treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics …