Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

▪ Abstract During the development of multicellular organisms, cells become different from
one another by changing their genetic program in response to transient stimuli. Long after …

The Polycomb system modifies chromatin and plays an essential role in repressing gene
expression to control normal mammalian development. However, the components and …

CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs
act as polycomb response elements (PREs) and are recognized by the polycomb silencing …

Polycomb group proteins preserve body patterning through development by maintaining
transcriptional silencing of homeotic genes. A long-standing hypothesis is that silencing …

Polycomb group (PcG) proteins exist in at least two biochemically distinct protein complexes,
the EED-EZH2 complex and the PRC1 complex, that respectively possess H3-K27 …

Summary The Polycomb-group (PcG) repressive complex-1 (PRC1) forms microscopically
visible clusters in nuclei; however, the impact of this cluster formation on transcriptional …

The Polycomb repressive system plays a fundamental role in controlling gene expression
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …

Polycomb group (PcG) proteins maintain the transcriptional silence of target genes through
many cycles of cell division. Here, we provide evidence for the sequential binding of PcG …

In mammals X inactivation is initiated by expression of Xist RNA and involves the recruitment
of Polycomb repressive complex 1 (PRC1) and 2 (PRC2), which mediate chromosome‐wide …