Inflammatory lung diseases like asthma bronchiale, chronic obstructive pulmonary disease
and allergic airway inflammation are widespread public diseases that constitute an …

Sequential expression of claudins, a family of tight junction proteins, along the nephron
mirrors the sequential expression of ion channels and transporters. Only by the interplay of …

Cisplatin is one of the most widely used chemotherapeutic agents for the treatment of solid
tumours. The major dose-limiting factor is nephrotoxicity, in particular in the proximal tubule …

Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …

Abstract In 1959 Russell and Burch stated that “Mammalian tissue cultures have become
one of the most important replacement techniques”. Although they would likely be …

The kidney is a major target for drug-induced injury, primarily due the fact that it transports a
wide variety of chemical entities into and out of the tubular lumen. Here, we investigated the …

Background Chronic psychological stress is associated with increased intestinal epithelial
permeability and visceral hyperalgesia. Lubiprostone, an agonist for chloride channel‐2 …

Physiological studies in leaky epithelia, like kidney proximal tubules and the small intestine,
have documented water transport via both transcellular and paracellular pathways. The …

The kidney is a major target organ for toxicity. Incidence of chronic kidney disease (CKD) is
increasing at an alarming rate due to factors such as increasing population age and …

The kidney is a frequent target for organ-specific toxicity as a result of its primary function in
controlling body fluids, for example, via resorption of amino acids, peptides, nutrients, ions …