Forgetting as a form of adaptive engram cell plasticity
TJ Ryan, PW Frankland - Nature Reviews Neuroscience, 2022 - nature.com
One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …
Therapeutic targeting of 3′, 5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
GS Baillie, GS Tejeda, MP Kelly - Nature reviews Drug discovery, 2019 - nature.com
Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …
pursued as therapeutic targets for several diseases, including those affecting the nervous …
The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function
Dendritic spines are the major sites of synaptic transmission in the central nervous system.
Alterations in the strength of synaptic connections directly affect the neuronal …
Alterations in the strength of synaptic connections directly affect the neuronal …
[HTML][HTML] Relations between sleep patterns early in life and brain development: a review
S Lokhandwala, RMC Spencer - Developmental cognitive neuroscience, 2022 - Elsevier
Sleep supports healthy cognitive functioning in adults. Over the past decade, research has
emerged advancing our understanding of sleep's role in cognition during development …
emerged advancing our understanding of sleep's role in cognition during development …
[HTML][HTML] Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
Activity in hippocampal area CA1 is essential for consolidating episodic memories, but it is
unclear how CA1 activity patterns drive memory formation. We find that in the hours …
unclear how CA1 activity patterns drive memory formation. We find that in the hours …
[HTML][HTML] An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity
D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …
[HTML][HTML] Cofilin and actin dynamics: multiple modes of regulation and their impacts in neuronal development and degeneration
JR Bamburg, LS Minamide, ON Wiggan… - Cells, 2021 - mdpi.com
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …
Sleep loss drives acetylcholine-and somatostatin interneuron–mediated gating of hippocampal activity to inhibit memory consolidation
Sleep loss disrupts consolidation of hippocampus-dependent memory. To characterize
effects of learning and sleep loss, we quantified activity-dependent phosphorylation of …
effects of learning and sleep loss, we quantified activity-dependent phosphorylation of …
Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders
Phosphodiesterases (PDE) are a diverse family of enzymes (11 isoforms so far identified)
responsible for the degradation of cyclic adenosine monophosphate (cAMP) and cyclic …
responsible for the degradation of cyclic adenosine monophosphate (cAMP) and cyclic …
The function (s) of sleep
Sleep is a highly conserved phenomenon in endotherms, and therefore it must serve at least
one basic function across this wide range of species. What that function is remains one of …
one basic function across this wide range of species. What that function is remains one of …