Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
S Trapp, DI Brierley - British Journal of Pharmacology, 2022 - Wiley Online Library
This review considers the similarities and differences between the physiological systems
regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It …
regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It …
[HTML][HTML] Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms
JP Krieger - Peptides, 2020 - Elsevier
The gut-brain hormone glucagon-like peptide-1 (GLP-1) has received immense attention
over the last couple of decades for its widespread metabolic effects. Notably, intestinal GLP …
over the last couple of decades for its widespread metabolic effects. Notably, intestinal GLP …
[HTML][HTML] GDF15 induces anorexia through nausea and emesis
Summary Growth differentiation factor 15 (GDF15) is a cytokine that reduces food intake
through activation of hindbrain GFRAL-RET receptors and has become a keen target of …
through activation of hindbrain GFRAL-RET receptors and has become a keen target of …
Preproglucagon neurons in the nucleus of the solitary tract are the main source of brain GLP-1, mediate stress-induced hypophagia, and limit unusually large intakes …
Centrally administered glucagon-like peptide 1 (GLP-1) supresses food intake. Here we
demonstrate that GLP-1–producing (PPG) neurons in the nucleus tractus solitarii (NTS) are …
demonstrate that GLP-1–producing (PPG) neurons in the nucleus tractus solitarii (NTS) are …
Enteroendocrine cell regulation of the gut-brain axis
JR Barton, AK Londregan, TD Alexander… - Frontiers in …, 2023 - frontiersin.org
Enteroendocrine cells (EECs) are an essential interface between the gut and brain that
communicate signals about nutrients, pain, and even information from our microbiome …
communicate signals about nutrients, pain, and even information from our microbiome …
New insights into beta-cell GLP-1 receptor and cAMP signaling
A Tomas, B Jones, C Leech - Journal of molecular biology, 2020 - Elsevier
Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells
has led to the development of established GLP-1R-based therapies for the long-term …
has led to the development of established GLP-1R-based therapies for the long-term …
The role of cAMP in beta cell stimulus–secretion and intercellular coupling
Pancreatic beta cells secrete insulin in response to stimulation with glucose and other
nutrients, and impaired insulin secretion plays a central role in development of diabetes …
nutrients, and impaired insulin secretion plays a central role in development of diabetes …
Ghrelin and glucagon-like peptide-1: a gut-brain axis battle for food reward
L Decarie-Spain, SE Kanoski - Nutrients, 2021 - mdpi.com
Eating behaviors are influenced by the reinforcing properties of foods that can favor
decisions driven by reward incentives over metabolic needs. These food reward-motivated …
decisions driven by reward incentives over metabolic needs. These food reward-motivated …
A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss
Mechanisms underlying long-term sustained weight loss and glycemic normalization after
obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 …
obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 …
Glucagon‐like peptide‐1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?
Introduced less than two decades ago, glucagon‐like peptide‐1 receptor agonists rapidly
reshaped the field of Type 2 diabetes mellitus (T2DM) care by providing glycaemic control in …
reshaped the field of Type 2 diabetes mellitus (T2DM) care by providing glycaemic control in …