The impact of tissue engineering has extended beyond a traditional focus in medicine to the
rapidly growing realm of biohybrid robotics. Leveraging living actuators as functional …

Heart disease is a significant burden on global health care systems and is a leading cause
of death each year. To improve our understanding of heart disease, high quality disease …

Cardiovascular diseases are caused by hereditary factors, environmental conditions, and
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …

The limited regenerative capacity of the human body, in conjunction with a shortage of
healthy autologous tissue, has created an urgent need for alternative grafting materials. A …

Advancing human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM)
technology will lead to significant progress ranging from disease modeling, to drug …

The hierarchical design and adaptive functionalities of biological tissues are driven by
dynamic biochemical, electrical, and mechanical signaling between cells and their …

Heart-on-chip emerged as a potential tool for cardiac tissue engineering, recapitulating key
physiological cues in cardiac pathophysiology. Controlled electrical stimulation and the …

The importance of dynamic mechanical control over the cellular microenvironment has long
been appreciated. In a recent issue of Device, Raman and colleagues design a clever yet …

The anisotropic organization of cells and the extracellular matrix (ECM) is essential for the
physiological function of numerous biological tissues, including the myocardium. This …

Myocardial ischemic injury and its resolution are the key determinants of morbidity or
mortality in heart failure. The cause and duration of ischemia in patients vary. Numerous …