[HTML][HTML] Toll-like receptor–mediated intestinal inflammatory imbalance in the pathogenesis of necrotizing enterocolitis

DJ Hackam, CP Sodhi - Cellular and Molecular Gastroenterology and …, 2018 - Elsevier
Necrotizing enterocolitis (NEC) remains the leading cause of death from gastrointestinal
disease in premature infants and attacks the most fragile patients at a time when they …

Necrotizing enterocolitis, gut microbes, and sepsis

JW Duess, ME Sampah, CM Lopez, K Tsuboi… - Gut …, 2023 - Taylor & Francis
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants and the
leading cause of death and disability from gastrointestinal disease in this vulnerable …

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation

Y Koike, B Li, N Ganji, H Zhu, H Miyake, Y Chen… - Nature …, 2020 - nature.com
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high
mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal …

Current research on the epidemiology, pathogenesis, and management of necrotizing enterocolitis

S Eaton, CM Rees, NJ Hall - Neonatology, 2017 - karger.com
Despite decades of research on necrotizing enterocolitis, we still do not fully understand the
pathogenesis of the disease, or how to prevent or how to treat it. However, as a result of …

CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants

OO Olaloye, P Liu, JM Toothaker, BT McCourt… - Journal of Experimental …, 2021 - rupress.org
Necrotizing enterocolitis (NEC) is a severe gastrointestinal complication of prematurity.
Using suspension and imaging mass cytometry coupled with single-cell RNA sequencing …

Necrotizing enterocolitis in premature infants and newborns

MJ Mϋller, T Paul, S Seeliger - Journal of neonatal-perinatal …, 2016 - content.iospress.com
Necrotizing enterocolitis (NEC) is the most common acquired disease of the gastrointestinal
tract (GIT) in premature infants and newborns. It is defined as an ulcerative inflammation of …

Pathophysiology of necrotizing enterocolitis: an update

C Bazacliu, J Neu - Current pediatric reviews, 2019 - ingentaconnect.com
NEC is a devastating disease that, once present, is very difficult to treat. In the absence of an
etiologic treatment, preventive measures are required. Advances in decoding the …

An overview of systematic reviews of randomized-controlled trials for preventing necrotizing enterocolitis in preterm infants

T Xiong, A Maheshwari, J Neu, A Ei-Saie, M Pammi - Neonatology, 2020 - karger.com
Necrotizing enterocolitis (NEC) remains a major cause for neonatal mortality and morbidity
in preterm infants. The purpose of this review was to summarize evidence from systematic …

Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis

Y Chen, Y Koike, L Chi, A Ahmed… - Disease Models & …, 2019 - journals.biologists.com
Major risk factors for necrotizing enterocolitis (NEC) are formula feeding and prematurity;
however, their pathogenic mechanisms are unknown. Here, we found that insufficient …

Creatine kinase in ischemic and inflammatory disorders

D Kitzenberg, SP Colgan, LE Glover - Clinical and translational medicine, 2016 - Springer
The creatine/phosphocreatine pathway plays a conserved and central role in energy
metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of …