Diaryl esters of α-aminophosphonates are a group of low molecular weight inhibitors of
serine proteases. For over 30 years these molecules have captured the attention of …

The genomic revolution has created a wealth of information regarding the fundamental
genetic code that defines the inner workings of a cell. However, it has become clear that …

TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing
to its highly localized expression in the prostate and its overexpression in neoplastic …

Recent advances in global genomic and proteomic methods have lead to a greater
understanding of how genes and proteins function in complex networks within a cell. One of …

We have shown that proteinase-activated receptor-2 (PAR 2) activation in the airways leads
to allergic sensitization to concomitantly inhaled Ags, thus implicating PAR 2 in the …

The exact mechanism (s) by which kallikrein-related peptidases (KLKs) function, their levels
of activity and their potential endogenous targets in vivo have only recently begun to be …

A series of diphenylphosphonate-based probes were developed for the trypsin-like serine
proteases. These probes selectively target serine proteases rather than general serine …

Activity-based probes (ABP) are molecules that bind covalently to the active form of an
enzyme family, making them an attractive tool for target and biomarker identification and …

Serine hydrolases play crucial biological roles and are important therapeutic targets in many
clinical applications. Activity‐based protein profiling of serine hydrolases by using …

Due to its fast international spread and substantial mortality, the coronavirus disease COVID-
19 evolved to a global threat. Since there is currently no causative drug against this viral …