The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

Since its introduction to Ca2+ signaling in 1997, 2‐aminoethoxydiphenyl borate (2‐APB)
has been used in many studies to probe for the involvement of inositol 1, 4, 5‐trisphosphate …

Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …

The two membrane proteins, STIM1 and Orai1, have each been shown to be essential for
the activation of store-operated channels (SOC). Yet, how these proteins functionally interact …

The mechanism of receptor-induced activation of the ubiquitously expressed family of
mammalian canonical transient receptor potential (TRPC) channels has been the focus of …

Ca 2+ entry through store-operated Ca 2+ release-activated Ca 2+(CRAC) channels is
essential for T-cell activation and proliferation. Recently, it has been shown that 3, 5 …

Six of the mammalian transient receptor potential (TRP) ion channel subtypes are
nonselective cation channels that can be activated by increases or decreases in ambient …