Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …

The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

The mechanical properties of cells influence their cellular and subcellular functions,
including cell adhesion, migration, polarization, and differentiation, as well as organelle …

Collective cell migration is essential for morphogenesis, tissue remodelling and cancer
invasion,. In vivo, groups of cells move in an orchestrated way through tissues. This …

The earliest aspects of human embryogenesis remain mysterious. To model patterning
events in the human embryo, we used colonies of human embryonic stem cells (hESCs) …

A single mouse blastomere from an embryo until the 8-cell stage can generate an entire
blastocyst. Whether laboratory-cultured cells retain a similar generative capacity remains …

Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but
assessing their consistency and reproducibility across iPSC lines, and reducing the …

Classic embryological studies have successfully applied genetics and cell biology principles
to understand embryonic development. However, it remains unresolved how mechanics, as …

Embryonic development is orchestrated by robust and complex regulatory mechanisms
acting at different scales of organization. In vivo studies are particularly challenging for …

Living cells and tissues experience physical forces and chemical stimuli in the human body.
The process of converting mechanical forces into biochemical activities and gene …