Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
Action mechanisms of curcumin in Alzheimer's disease and its brain targeted delivery
D Ege - Materials, 2021 - mdpi.com
AD is a chronic neurodegenerative disease. Many different signaling pathways, such as
Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer's disease …
Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer's disease …
Acetylcholinesterase and butyrylcholinesterase inhibitory activities of khellactone coumarin derivatives isolated from Peucedanum japonicum Thurnberg
JH Heo, BH Eom, HW Ryu, MG Kang, JE Park… - Scientific Reports, 2020 - nature.com
Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …
Design and development of benzyl piperazine linked 5-phenyl-1, 2, 4-triazole-3-thione conjugates as potential agents to combat Alzheimer's disease
Our present work demonstrates the molecular hybridization-assisted design, synthesis, and
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
Antibacterial activity and molecular docking studies of a selected series of hydroxy-3-arylcoumarins
Antibiotic resistance is one of the main public health concerns of this century. This resistance
is also associated with oxidative stress, which could contribute to the selection of resistant …
is also associated with oxidative stress, which could contribute to the selection of resistant …
Phenoxyethyl piperidine/morpholine derivatives as PAS and CAS inhibitors of cholinesterases: insights for future drug design
Acetylcholinesterase (AChE) catalyzes the conversion of Aβ peptide to its aggregated form
and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also …
and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also …
Synthesis of 4-substituted benzyl-2-triazole-linked-tryptamine-paeonol derivatives and evaluation of their selective inhibitions against butyrylcholinesterase and …
JM Oh, Y Kang, JH Hwang, JH Park, WH Shin… - International Journal of …, 2022 - Elsevier
Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors are being used and
developed to treat Alzheimer's disease (AD), a major type of dementia patients. Fifteen 4 …
developed to treat Alzheimer's disease (AD), a major type of dementia patients. Fifteen 4 …
Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease
Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1, 3, 4-oxadiazoles
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …
Neuroprotective effect of terpenoids recovered from olive oil by-products
ZJ Suárez Montenegro, G Álvarez-Rivera… - Foods, 2021 - mdpi.com
The neuroprotective potential of 32 natural extracts obtained from olive oil by-products was
investigated. The online coupling of supercritical fluid extraction (SFE) and dynamic …
investigated. The online coupling of supercritical fluid extraction (SFE) and dynamic …