Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance
The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens
are outpacing the development of new antibiotics, but antivirulence agents provide an …
are outpacing the development of new antibiotics, but antivirulence agents provide an …
Plant polyphenols as antioxidant and antibacterial agents for shelf‐life extension of meat and meat products: Classification, structures, sources, and action …
Oxidative processes and meat spoilage bacteria are major contributors to decreasing the
shelf‐life of meat and meat products. Oxidative processes occur during processing, storage …
shelf‐life of meat and meat products. Oxidative processes occur during processing, storage …
Iron homeostasis in host defence and inflammation
Iron is an essential trace element for multicellular organisms and nearly all microorganisms.
Although iron is abundant in the environment, common forms of iron are minimally soluble …
Although iron is abundant in the environment, common forms of iron are minimally soluble …
Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections
CH Goss, Y Kaneko, L Khuu, GD Anderson… - Science translational …, 2018 - science.org
The lack of new antibiotics is among the most critical challenges facing medicine. The
problem is particularly acute for Gram-negative bacteria. An unconventional antibiotic …
problem is particularly acute for Gram-negative bacteria. An unconventional antibiotic …
8-Hydroxyquinolines in medicinal chemistry: A structural perspective
V Oliveri, G Vecchio - European journal of medicinal chemistry, 2016 - Elsevier
Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …
Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges
Acinetobacter is a complex genus, and historically, there has been confusion about the
existence of multiple species. The species commonly cause nosocomial infections …
existence of multiple species. The species commonly cause nosocomial infections …
Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa
The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both
in vitro and in animal models of infection and is considered an ideal target for the …
in vitro and in animal models of infection and is considered an ideal target for the …
Antimicrobial activity of gallium compounds on ESKAPE pathogens
S Hijazi, D Visaggio, M Pirolo, E Frangipani… - Frontiers in cellular …, 2018 - frontiersin.org
ESKAPE bacteria are a major cause of multidrug-resistant infections, and new drugs are
urgently needed to combat these pathogens. Given the importance of iron in bacterial …
urgently needed to combat these pathogens. Given the importance of iron in bacterial …
Genetics, epidemiology, and clinical manifestations of multidrug-resistant Acinetobacter baumannii
P Nasr - Journal of Hospital Infection, 2020 - Elsevier
Acinetobacter baumannii infections have become an emerging health concern in hospitals
across the world and are often associated with nosocomial infections with poorer clinical …
across the world and are often associated with nosocomial infections with poorer clinical …
Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo
Iron is an essential metal that fine-tunes the innate immune response by regulating
macrophage function, but an integrative view of transcriptional and metabolic responses to …
macrophage function, but an integrative view of transcriptional and metabolic responses to …