MicroRNA in teleost fish

TT Bizuayehu, I Babiak - Genome biology and evolution, 2014 - academic.oup.com
MicroRNAs (miRNAs) are transcriptional and posttranscriptional regulators involved in
nearly all known biological processes in distant eukaryotic clades. Their discovery and …

New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing

AM Burroughs, Y Ando, L Aravind - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Our understanding of the pervasive involvement of small RNAs in regulating diverse
biological processes has been greatly augmented by recent application of deep …

PAPD5-mediated 3′ adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease

J Boele, H Persson, JW Shin, Y Ishizu… - Proceedings of the …, 2014 - National Acad Sciences
Next-generation sequencing experiments have shown that microRNAs (miRNAs) are
expressed in many different isoforms (isomiRs), whose biological relevance is often unclear …

TUT 7 controls the fate of precursor micro RNA s by using three different uridylation mechanisms

B Kim, M Ha, L Loeff, H Chang, DK Simanshu… - The EMBO …, 2015 - embopress.org
Terminal uridylyl transferases (TUT s) function as integral regulators of micro RNA (mi RNA)
biogenesis. Using biochemistry, single‐molecule, and deep sequencing techniques, we …

Characterization of phosphorus-regulated miR399 and miR827 and their isomirs in barley under phosphorus-sufficient and phosphorus-deficient conditions

M Hackenberg, BJ Shi, P Gustafson, P Langridge - BMC plant biology, 2013 - Springer
Background miR399 and miR827 are both involved in conserved phosphorus (P) deficiency
signalling pathways. miR399 targets the PHO2 gene encoding E2 enzyme that negatively …

A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis

X Liu, Q Zheng, N Vrettos, M Maragkakis, P Alexiou… - Molecular cell, 2014 - cell.com
MicroRNAs (miRNAs) are essential for regulation of gene expression. Though numerous
miRNAs have been identified by high-throughput sequencing, few precursor miRNAs (pre …

miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A

K Ikeda, K Horie-Inoue, T Ueno, T Suzuki, W Sato… - Scientific reports, 2015 - nature.com
Breast cancer is a hormone-dependent cancer and usually treated with endocrine therapy
using aromatase inhibitors or anti-estrogens such as tamoxifen. A majority of breast cancer …

Comparison of hepatocellular carcinoma miRNA expression profiling as evaluated by next generation sequencing and microarray

Y Murakami, T Tanahashi, R Okada, H Toyoda… - PloS one, 2014 - journals.plos.org
MicroRNA (miRNA) expression profiling has proven useful in diagnosing and understanding
the development and progression of several diseases. Microarray is the standard method for …

Beta cell 5′-shifted isomiRs are candidate regulatory hubs in type 2 diabetes

J Baran-Gale, EE Fannin, CL Kurtz, P Sethupathy - PloS one, 2013 - journals.plos.org
Next-generation deep sequencing of small RNAs has unveiled the complexity of the
microRNA (miRNA) transcriptome, which is in large part due to the diversity of miRNA …

Deep annotation of mouse iso-miR and iso-moR variation

H Zhou, ML Arcila, Z Li, EJ Lee, C Henzler… - Nucleic acids …, 2012 - academic.oup.com
With a dataset of more than 600 million small RNAs deeply sequenced from mouse
hippocampal and staged sets of mouse cells that underwent reprogramming to induced …