[HTML][HTML] L-arginine attenuates dichlorvos-induced testicular toxicity in male Wistar rats by suppressing oxidative stress-dependent activation of caspase 3-mediated …

WA Saka, AE Adeogun, VI Adisa, A Olayioye… - Biomedicine & …, 2024 - Elsevier
Background The continuous use of pesticides, such as dichlorvos, is a common agricultural
and domestic practice. However, it is associated with shortfalls like testicular toxicity through …

Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models

RE Akhigbe, AF Odetayo, TM Akhigbe, MA Hamed… - Heliyon, 2024 - cell.com
Testicular torsion is a urological emergency that involves the twisting of the spermatic cord
along its course. Compelling pieces of evidence have implicated oxidative stress-sensitive …

Effectiveness of continuous positive airway pressure therapy on romantic relationships and intimacy among individuals with obstructive sleep apnea: A systematic …

V Poletti, EG Battaglia, P Banfi… - Journal of Sleep …, 2025 - Wiley Online Library
Obstructive sleep apnea is a common yet often overlooked chronic sleep disorder with
significant health implications globally. Bedpartners play a vital role in motivating individuals …

Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats

EE Besong, TM Akhigbe, JN Obimma… - … Trace Element Research, 2024 - Springer
Arsenic is associated with male reproductive toxicity through histone deacetylation and
oxido-inflammatory injury. Notwithstanding, short-chain fatty acids such as acetate exert anti …

Zinc protects against lead-induced testicular damage via modulation of steroidogenic and xanthine oxidase/uric acid/caspase 3-mediated apoptotic signaling in male …

EE Besong, PJ Ashonibare, OO Obembe… - The Aging …, 2023 - Taylor & Francis
Aim This study evaluated the effect of lead, with or without zinc co-administration, on
steroidogenic and xanthine oxidase (XO)/uric acid (UA)/caspase 3-mediated apoptotic …

Glutamine alleviates I/R-Induced intestinal injury and dysmotility via the downregulation of xanthine oxidase/uric acid signaling and lactate generation in wistar rats

RE Akhigbe, BOA Aminat, TM Akhigbe… - Journal of Surgical …, 2024 - Elsevier
Introduction Disruption of intestinal histoarchitecture and intestinal dysmotility is critical to
intestinal ischemia/reperfusion (IR) injury and xanthine oxidase (XO)/uric acid (UA) signaling …

Testicular toxicity in cisplatin-treated Wistar rats is mitigated by Daflon and associated with modulation of Nrf2/HO-1 and TLR4/NF-kB signaling

RE Akhigbe, OE Adelowo, EO Ajani… - Journal of Trace …, 2024 - Elsevier
Background Testicular toxicity is a complication of cisplatin therapy and it limits its use. Since
cisplatin-induced testicular damage is mediated by inflammation and oxidative stress …

Glutamine-mediated modulation of XO/uric acid/NF-kB signaling pathway ameliorates intestinal I/R-induced bacterial translocation and Cardiorenal inflammatory …

MA Hamed, OO Adegboyega, OI Ojo… - Cell Biochemistry and …, 2024 - Springer
This study explored the effect of intestinal ischaemia/reperfusion (I/R) on cardiorenal tissues.
The involvement of xanthine oxidase/uric acid/NF-kB signaling in intestinal I/R was also …

Inhibition of reactive oxygen species generation by N-Acetyl Cysteine can mitigate male germ cell toxicity induced by bisphenol analogs

SG Kim, JH Jeon, SH Shin, DC Varias, SH Moon… - Food and Chemical …, 2024 - Elsevier
The estrogen-like effect of bisphenol A (BPA) disrupting the maintenance of functional male
germ cells is associated with male sub-fertility. This study investigated toxicity of male germ …

Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis

EE Besong, TM Akhigbe, PA Oyedokun… - Toxicological …, 2024 - Springer
Lead exposure has been implicated in the aetiopathogenesis of male infertility via an
oxidative stress-sensitive pathway. Conversely, acetate has been shown to confer cellular …