RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …

Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …

Recent advances in interrogating RNA folding dynamics have shown the classical model of
RNA folding to be incomplete. Here, we pose three prominent questions for the field that are …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

RNA begins to fold as it is transcribed by an RNA polymerase. Consequently, RNA folding is
constrained by the direction and rate of transcription. Understanding how RNA folds into …

Cotranscriptional RNA folding is crucial for the timely control of biological processes, but
because of its transient nature, its study has remained challenging. While single-molecule …

Ribonucleoprotein (RNP) assembly typically begins during transcription when folding of the
newly synthesized RNA is coupled with the recruitment of RNA-binding proteins (RBPs) …

The synthesis of new ribosomes begins during transcription of the rRNA and is widely
assumed to follow an orderly 5′ to 3′ gradient. To visualize co-transcriptional assembly of …

Folding of RNA into secondary structures through intramolecular base pairing determines an
RNA's three-dimensional architecture and associated function. Simple RNA structures like …

RNAs begin to fold and function during transcription. Riboswitches undergo
cotranscriptional switching in the context of transcription elongation, RNA folding, and ligand …