Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …

This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …

Acetylation of the [var epsilon]-amino group of a lysine residue was first discovered with
histones in 1968, but the responsible enzymes, histone acetyltransferases and …

The mammalian cilium protrudes from the apical/lumenal surface of polarized cells and acts
as a sensor of environmental cues. Numerous developmental disorders and pathological …

Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two
counteracting enzyme families whose enzymatic activity controls the acetylation state of …

Understanding the cellular and molecular mechanisms underlying the formation and
maintenance of memories is a central goal of the neuroscience community. It is well …

Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein
dephosphorylation reactions in a highly regulated and selective manner. Recent studies …

Long-term memory formation requires transcription and protein synthesis. Over the past few
decades, a great amount of knowledge has been gained regarding the molecular players …

Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …