Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …

Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

In pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …

Polychromatic flow cytometry results in complex, multivariate datasets. To date, tools for the
aggregate analysis of these datasets across multiple specimens grouped by different …

The mammalian intestinal tract harbors a diverse community of trillions of microorganisms,
which have co-evolved with the host immune system for millions of years. Many of these …

Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …

Many viruses infect humans and most are controlled satisfactorily by the immune system
with limited damage to host tissues. Some viruses, however, do cause overt damage to the …

Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms
contributing to chronic inflammation and increased morbidity and mortality during …

The advent of combination antiretroviral therapy (cART) has significantly improved the
prognosis of human immunodeficiency virus (HIV)-infected individuals. However, individuals …