Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Most of the secreted and plasma membrane proteins are synthesized on membrane-bound
ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis
by activating the unfolded protein response (UPR). However, UPR can trigger cell death …

The endoplasmic reticulum (ER) is a critical organelle, storing the majority of calcium and
governing protein translation. Thus, it is crucial to keep the homeostasis in all ER …

Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a
promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated …