Cross-linking mass spectrometry (XL-MS) has matured into a potent tool to identify protein–
protein interactions or to uncover protein structures in living cells, tissues, or organelles. The …

Elucidating protein–protein interaction (PPI) networks and their structural features within
cells is central to understanding fundamental biology and associations of cell phenotypes …

Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …

Defining protein–protein interactions (PPIs) in their native environment is crucial to
understanding protein structure and function. Cross-linking–mass spectrometry (XL-MS) has …

Protein-protein interactions govern most cellular pathways and processes, and multiple
technologies have emerged to systematically map them. Assessing the error of interaction …

Crosslinking mass spectrometry has become a core technology in structural biology and is
expanding its reach towards systems biology. Its appeal lies in a rapid workflow, high …

Histone post-translational modifications (PTMs) are one of the main mechanisms of
epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such …

Cross-linking mass spectrometry (MS) has substantially matured as a method over the past
2 decades through parallel development in multiple labs, demonstrating its applicability to …

Cross-linking mass spectrometry (XL-MS) is an emergent technology for studying protein–
protein interactions (PPIs) and elucidating architectures of protein complexes. The …

Studying protein-protein interaction networks provide key evidence for the underlying
molecular mechanisms. Mass spectrometry-based proteomic approaches have been …