The return of the nucleus: transcriptional and epigenetic control of autophagy
Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …
[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease
J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …
threatens the health of the elderly and causes significant economic and social burdens. The …
[HTML][HTML] Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals
Immune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the
transcription factor Foxp3 functioning as the critical regulator of Treg cell development and …
transcription factor Foxp3 functioning as the critical regulator of Treg cell development and …
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells
The transcription factor Foxp3 is indispensable for the ability of regulatory T cells (Treg cells)
to suppress fatal inflammation. Here we characterized the role of Foxp3 in chromatin …
to suppress fatal inflammation. Here we characterized the role of Foxp3 in chromatin …
The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism
There are nearly 50 forkhead (FOX) transcription factors encoded in the human genome
and, due to sharing a common DNA binding domain, they are all thought to bind to similar …
and, due to sharing a common DNA binding domain, they are all thought to bind to similar …
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy
Autophagy is an evolutionarily conserved catabolic process involved in several
physiological and pathological processes,. Although primarily cytoprotective, autophagy can …
physiological and pathological processes,. Although primarily cytoprotective, autophagy can …
MicroRNA-200c and microRNA-141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer
Background Members of the microRNA (miR)-200 family, which are involved in tumor
metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain …
metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain …
FOXP3 controls an miR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cells
FOXP3 functions not only as the master regulator in regulatory T cells, but also as an X-
linked tumor suppressor. The tumor-suppressive activity of FOXP3 has been observed in …
linked tumor suppressor. The tumor-suppressive activity of FOXP3 has been observed in …
Megakaryocytic leukemia 1 bridges epigenetic activation of NADPH oxidase in macrophages to cardiac ischemia-reperfusion injury
Background: Excessive accumulation of reactive oxygen species (ROS), catalyzed by the
NADPH oxidases (NOX), is involved in the pathogenesis of ischemia-reperfusion (IR) injury …
NADPH oxidases (NOX), is involved in the pathogenesis of ischemia-reperfusion (IR) injury …
[HTML][HTML] miR-15a-5p inhibits metastasis and lipid metabolism by suppressing histone acetylation in lung cancer
Y Ni, Y Yang, J Ran, L Zhang, M Yao, Z Liu… - Free Radical Biology and …, 2020 - Elsevier
Metabolic reprogramme was a key characteristic of malignant tumors. Increased evidences
indicated that besides Warburg effect (abnormal glucose metabolism), abnormal lipid …
indicated that besides Warburg effect (abnormal glucose metabolism), abnormal lipid …