Fibrinogen molecules are comprised of two sets of disulfide‐bridged Aα‐, Bβ‐, and γ‐
chains. Each molecule contains two outer D domains connected to a central E domain by a …

Fibrin, a natural hydrogel, is the end product of the physiological blood coagulation cascade
and naturally involved in wound healing. Beyond its role in hemostasis, it acts as a local …

Fibrin is a natural biopolymer involved in the coagulation cascade. It acts as a reservoir for
growth factors, cells, and enzymes during wound healing and provides a scaffold for the …

Rationale: While thrombin is the key protease in thrombus formation, other coagulation
proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate …

A fraction of fibrinogen contains a differently spliced γ chain called γ′, which presents itself
mainly as heterodimer with the common γA chain as γA/γ′ fibrinogen. The γ′ chain differs …

Precise modulation of thrombin activity throughout the hemostatic response is essential for
efficient cessation of bleeding while preventing inappropriate clot growth or dissemination …

Fibrin clot formation is a key event in the development of thrombotic disease and is the final
step in a multifactor coagulation cascade. Fibrinogen is a large glycoprotein that forms the …

Antithrombin I (fibrin) is an important inhibitor of thrombin generation that functions by
sequestering thrombin in the forming fibrin clot, and also by reducing the catalytic activity of …

Although exosites 1 and 2 regulate thrombin activity by binding substrates and cofactors and
by allosterically modulating the active site, it is unclear whether there is direct allosteric …

The many splendors of¢ brin go far beyond its intrin-sic role in hemostasis. Fibrin indirectly
contributes to the healing of injured tissue through its ability to bind proenzymes, enzyme …