Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity
In conjugate, inactivated, recombinant, and toxoid vaccines, adjuvants are extensively and
essentially used for enhanced and long-lasting protective immune responses. Depending …
essentially used for enhanced and long-lasting protective immune responses. Depending …
Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants
S Flingai, M Czerwonko, J Goodman… - Frontiers in …, 2013 - frontiersin.org
In recent years, DNA vaccines have undergone a number of technological advancements
that have incited renewed interest and heightened promise in the field. Two such …
that have incited renewed interest and heightened promise in the field. Two such …
A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control
E Tondini, T Arakelian, K Oosterhuis, M Camps… - …, 2019 - Taylor & Francis
The combination of immune-stimulating strategies has the potency to improve
immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor …
immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor …
Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques
A Valentin, C Bergamaschi, M Rosati, M Angel… - Frontiers in …, 2022 - frontiersin.org
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …
Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles
As vaccine formulations have progressed from including live or attenuated strains of
pathogenic components for enhanced safety, developing new adjuvants to more effectively …
pathogenic components for enhanced safety, developing new adjuvants to more effectively …
Co-immunization of DNA and protein in the same anatomical sites induces superior protective immune responses against SHIV challenge
We compare immunogenicity and protective efficacy of an HIV vaccine comprised of env and
gag DNA and Env (Envelope) proteins by co-administration of the vaccine components in …
gag DNA and Env (Envelope) proteins by co-administration of the vaccine components in …
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit
IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To
maximize cytokine production from plasmid DNA, molecular steps controlling IL-12p70 …
maximize cytokine production from plasmid DNA, molecular steps controlling IL-12p70 …
[HTML][HTML] Tuberculosis vaccines–state of the art, and novel approaches to vaccine development
C da Costa, B Walker, A Bonavia - International Journal of Infectious …, 2015 - Elsevier
The quest for a vaccine that could have a major impact in reducing the current global burden
of TB disease in humans continues to be extremely challenging. Significant gaps in our …
of TB disease in humans continues to be extremely challenging. Significant gaps in our …
Harnessing recent advances in synthetic DNA and electroporation technologies for rapid vaccine development against COVID-19 and other emerging infectious …
DNA vaccines are considered as a third-generation vaccination approach in which antigenic
materials are encoded as DNA plasmids for direct in vivo production to elicit adaptive …
materials are encoded as DNA plasmids for direct in vivo production to elicit adaptive …
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge
We have previously shown that macaques vaccinated with DNA vectors expressing
SIVmac239 antigens developed potent immune responses able to reduce viremia upon high …
SIVmac239 antigens developed potent immune responses able to reduce viremia upon high …