Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …

The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …

Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Healthy central nervous system (CNS) development and function require an intricate and
balanced bidirectional communication between neurons and glia cells. In this review, we …