The balance of STING signaling orchestrates immunity in cancer
KRB Lanng, EL Lauridsen, MR Jakobsen - Nature Immunology, 2024 - nature.com
Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
Targeting STING in cancer: Challenges and emerging opportunities
K Zhao, J Huang, Y Zhao, S Wang, J Xu… - Biochimica et Biophysica …, 2023 - Elsevier
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
pathway is a key pathway through which the host regulates immune responses by …
pathway is a key pathway through which the host regulates immune responses by …
[HTML][HTML] Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
Tissue memory relies on stem cell priming in distal undamaged areas
C Levra Levron, M Watanabe, V Proserpio… - Nature Cell …, 2023 - nature.com
Epithelial cells that participated in wound repair elicit a more efficient response to future
injuries, which is believed to be locally restricted. Here we show that cell adaptation …
injuries, which is believed to be locally restricted. Here we show that cell adaptation …
cGAS–STING signalling in cancer: striking a balance with chromosomal instability
B Beernaert, EE Parkes - Biochemical Society Transactions, 2023 - portlandpress.com
Chromosomal instability (CIN) is a hallmark of cancer that drives tumour evolution. It is now
recognised that CIN in cancer leads to the constitutive production of misplaced DNA in the …
recognised that CIN in cancer leads to the constitutive production of misplaced DNA in the …
Uveal melanoma metastasis
Simple Summary Survival after diagnosis of metastatic uveal melanoma has not significantly
improved over decades, most patients die within a year from diagnosis. Uveal melanoma is …
improved over decades, most patients die within a year from diagnosis. Uveal melanoma is …
Single-cell RNA sequencing in melanoma: what have we learned so far?
Over the past decade, there have been remarkable improvements in the treatment and
survival rates of melanoma patients. Treatment resistance remains a persistent challenge …
survival rates of melanoma patients. Treatment resistance remains a persistent challenge …
[HTML][HTML] SIRT7 downregulation promotes breast cancer metastasis via LAP2α-induced chromosomal instability
Q Huo, S Chen, J Zhuang, C Quan… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Chromosomal instability (CIN) plays an important role in the initiation and progression of
carcinomas. However, the regulatory mechanism of metastasis mediated by CIN in breast …
carcinomas. However, the regulatory mechanism of metastasis mediated by CIN in breast …
Cerivastatin synergizes with trametinib and enhances its efficacy in the therapy of uveal melanoma
Simple Summary Uveal melanoma is a rare and aggressive disease. Gα-proteins GNAQ
and GNA11 are driver mutations that activate MAP kinase and YAP/TAZ pathways. BAP1 …
and GNA11 are driver mutations that activate MAP kinase and YAP/TAZ pathways. BAP1 …
Single cell RNA-sequencing in uveal melanoma: Advances in heterogeneity, tumor microenvironment and immunotherapy
S Tang, Y Zhang, S Huang, T Zhu, X Huang - Frontiers in Immunology, 2024 - frontiersin.org
Uveal melanoma (UM) is a highly aggressive and fatal tumor in the eye, and due the special
biology of UM, immunotherapy showed little effect in UM patients. To improve the efficacy of …
biology of UM, immunotherapy showed little effect in UM patients. To improve the efficacy of …