The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

The circadian rhythm is crucial for physiological and behavioral functions. Chronotype,
which represents individual preferences for activity and performance, is associated with …

Microplastics (MPs) may pollute drinking water, accumulate in the food chain, and release
toxic chemicals that may cause a variety of diseases. The detrimental effects of MPs on …

Numerous physiological functions exhibit substantial circadian oscillations. In the kidneys,
renal plasma flow, the glomerular filtration rate and tubular reabsorption and/or secretion …

Melatonin is the primary circadian output signal from the brain and is mainly synthesized in
pinealocytes. The rhythm and secretion of melatonin are under the control of an …

Large-scale genomic and transcriptomic initiatives offer unprecedented insight into complex
traits, but clinical translation remains limited by variant-level associations without biological …

The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse
and extensive processes throughout the body. The clock mechanism comprises a core …