Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Clioquinol was produced as a topical antiseptic and marketed as an oral intestinal
amebicide in 1934, being used to treat a wide range of intestinal diseases. In the early …

Trace elements such as iron (Fe), zinc (Zn), copper (Cu), and manganese (Mn) are
absorbed from food via the gastrointestinal tract, transported into the brain, and play central …

A few symptomatic drugs are currently available for Alzheimer's Disease (AD) therapy, but
these molecules are only able to temporary improve the cognitive capacity of the patients if …

Prion diseases, also known as transmissible spongiform encephalopathies, are invariably
fatal neurodegenerative diseases for which there are no efficacious treatments. Thousands …

Prion diseases are progressive and transmissive neurodegenerative diseases. The
conformational conversion of normal cellular prion protein (PrPC) into abnormal pathogenic …

Prion diseases are progressive neurodegenerative diseases that are associated with the
conversion of normal cellular prion protein (PrPC) to abnormal pathogenic prion protein …

The translocation of synaptic Zn2+ to the cytosolic compartment has been studied to
understand Zn2+ neurotoxicity in neurological diseases. However, it is unknown whether the …

Clioquinol (CQ) was associated with cases of transient global amnesia and with the
neurodegenerative syndrome subacute myelo-optico-neuropathy (SMON) in humans …

AIMS: The misfolding and the aggregation of specific proteins are key features of
neurodegenerative diseases, specifically Transmissible Spongiform Encephalopathies …