Clostridium difficile infection

WK Smits, D Lyras, DB Lacy, MH Wilcox… - Nature reviews Disease …, 2016 - nature.com
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life
threatening, especially in elderly people and in patients who have dysbiosis of the gut …

Understanding Clostridium difficile colonization

MJT Crobach, JJ Vernon, VG Loo… - Clinical microbiology …, 2018 - Am Soc Microbiol
Clostridium difficile is the main causative agent of antibiotic-associated and health care-
associated infective diarrhea. Recently, there has been growing interest in alternative …

SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection

P Feuerstadt, TJ Louie, B Lashner… - … England Journal of …, 2022 - Mass Medical Soc
Background Current therapies for recurrent Clostridioides difficile infection do not address
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …

[HTML][HTML] Changes in prevalence of health care–associated infections in US hospitals

SS Magill, E O'Leary, SJ Janelle… - … England Journal of …, 2018 - Mass Medical Soc
Background A point-prevalence survey that was conducted in the United States in 2011
showed that 4% of hospitalized patients had a health care–associated infection. We …

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for …

LC McDonald, DN Gerding, S Johnson… - Clinical infectious …, 2018 - academic.oup.com
Triptolide (TP), a traditional Chinese medicine, has been reported to be effective in the
treatment of autoimmune diseases and exerting antineoplastic activity in several human …

Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study

J Liu, JA Platts-Mills, J Juma, F Kabir, J Nkeze, C Okoi… - The Lancet, 2016 - thelancet.com
Background Diarrhoea is the second leading cause of mortality in children worldwide, but
establishing the cause can be complicated by diverse diagnostic approaches and varying …

[HTML][HTML] Nosocomial infections

A Sikora, F Zahra - 2020 - europepmc.org
Objectives: Identify the etiology of nosocomial infections. Describe the appropriate
evaluation of nosocomial infections. Explain the treatment options available for nosocomial …

Effect of Fecal Microbiota Transplantation on Recurrence in Multiply Recurrent Clostridium difficile Infection: A Randomized Trial

CR Kelly, A Khoruts, C Staley… - Annals of internal …, 2016 - acpjournals.org
Background: To date, evidence for the efficacy of fecal microbiota transplantation (FMT) in
recurrent Clostridium difficile infection (CDI) has been limited to case series and open-label …

ACG clinical guidelines: prevention, diagnosis, and treatment of Clostridioides difficile infections

CR Kelly, M Fischer, JR Allegretti… - Official journal of the …, 2021 - journals.lww.com
Clostridioides difficile infection occurs when the bacterium produces toxin that causes
diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to …

Clostridium difficile infection: epidemiology, diagnosis and understanding transmission

JSH Martin, TM Monaghan, MH Wilcox - … reviews Gastroenterology & …, 2016 - nature.com
Clostridium difficile infection (CDI) continues to affect patients in hospitals and communities
worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic megacolon …