Polyphenols: multipotent therapeutic agents in neurodegenerative diseases

KS Bhullar, HPV Rupasinghe - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Aging leads to numerous transitions in brain physiology including synaptic dysfunction and
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …

Quercetin: a bioactive compound imparting cardiovascular and neuroprotective benefits: scope for exploring fresh produce, their wastes, and by-products

IUH Bhat, R Bhat - Biology, 2021 - mdpi.com
Simple Summary The present review summarizes the generated hypothesis and critical role
of quercetin in cardiovascular and neuroprotective diseases reported over the last decade …

Polyphenols beyond barriers: a glimpse into the brain

I Figueira, R Menezes, D Macedo… - Current …, 2017 - ingentaconnect.com
Background: Ageing can be simply defined as the process of becoming older, which is
genetically determined but also environmentally modulated. With the continuous increase of …

Anti-inflammatory effects of dietary polyphenols through inhibitory activity against metalloproteinases

T Suzuki, T Ohishi, H Tanabe, N Miyoshi, Y Nakamura - Molecules, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) are zinc-dependent metalloproteinases that play
important roles in a variety of diseases, including cancer, cardiovascular disease, diabetes …

Application of quercetin in neurological disorders: From nutrition to nanomedicine

E Amanzadeh, A Esmaeili, S Rahgozar… - Reviews in the …, 2019 - degruyter.com
Quercetin is a polyphenolic flavonoid, which is frequently found in fruits and vegetables. The
antioxidant potential of quercetin has been studied from subcellular compartments, that is …

Multi-target drug with potential applications: violacein in the spotlight

N Durán, G Nakazato, M Durán, IR Berti… - World Journal of …, 2021 - Springer
The aim of the current review is to address updated research on a natural pigment called
violacein, with emphasis on its production, biological activity and applications. New …

Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia: a molecular docking study exploring possible neuroprotection

AK Pandey, P Bhattacharya, SC Shukla… - Neural regeneration …, 2015 - journals.lww.com
The main pathophysiology of cerebral ischemia is the structural alteration in the
neurovascular unit, coinciding with neurovascular matrix degradation. Resveratrol has been …

Acid‐sensing ion channels as potential therapeutic targets in neurodegeneration and neuroinflammation

A Ortega-Ramírez, R Vega, E Soto - Mediators of inflammation, 2017 - Wiley Online Library
Acid‐sensing ion channels (ASICs) are a family of proton‐sensing channels that are voltage
insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by …

Recent advances on the neuroprotective potential of antioxidants in experimental models of Parkinson's disease

S Koppula, H Kumar, SV More, BW Kim, IS Kim… - International journal of …, 2012 - mdpi.com
Parkinson's disease (PD), a neurodegenerative movement disorder of the central nervous
system (CNS) is characterized by a progressive loss of dopaminergic neurons in the …

Inhibition of Gelatinases (MMP-2 and MMP-9) by Withania somnifera Phytochemicals Confers Neuroprotection in Stroke: An In Silico Analysis

G Kumar, R Patnaik - Interdisciplinary Sciences: Computational Life …, 2018 - Springer
A stroke or cerebrovascular accident is a serious, life-threatening medical condition that
occurs when the blood supply to part of the brain is severely reduced or cut off, depriving …